原著論文「キャリアオイルのチロシナーゼ活性阻害およびメラニン産生抑制作用. 吉金優、熊谷千津、島上和則、手塚千史、野田信三、堀田龍志、村上志緒、山本芳邦、沢村正義.アロマテラピー学雑誌 Vol.15, No.1, 54-62, 2015」

Abstract : This study was performed to investigate the safety and functional properties of 16 kinds of carrier oils for aromatherapy. Furanocoumarins, which are present in some plants, are well known to cause cutaneous phototoxicity under ultraviolet radiation. Generally, the quantitative extraction of furanocoumarins from oils takes time and is labor intensive owing to the complexity of the process. We have developed a one-step extraction method that drastically reduces working time. In this first trial to determine furanocoumarin presence in oil samples, psoralen, xanthotoxin, bergapten, and isoimpinellin were not detected in any of the carrier oil samples. Biochemical studies were also performed, and all of the carrier oil samples showed inhibitory effects on mushroom tyrosinase activity, although jojoba oil exhibited little inhibiting. Further support for this inhibitory property is provided by the observation of melanogenesis in mouse B16 melanoma cells. These results promise to support the current research on the safety and skin-lightening potential of carrier oils.
Key words : carrier oil, furanocoumarin, tyrosinase, melanin, skin-lightening